The Role of Inflammasomes in Atherosclerosis and Stroke Pathogenesis

Inflammation is a devastating outcome of cerebrovascular diseases (CVD), namely stroke and atherosclerosis. Numerous studies over the decade have shown that inflammasomes play a role in mediating inflammatory reactions post cellular injury occurring after a stroke or a rupture of an atherosclerotic...

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Published inCurrent pharmaceutical design Vol. 26; no. 34; p. 4234
Main Authors Sarmah, Deepaneeta, Datta, Aishika, Raut, Swapnil, Sarkar, Ankan, Shah, Birva, Bohra, Mariya, Singh, Upasna, Jagtap, Priya, Baidya, Falguni, Kalia, Kiran, Wang, Xin, Dave, Kunjan R, Yavagal, Dileep R, Bhattacharya, Pallab
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2020
Subjects
Atherosclerosis - drug therapy
Humans
Inflammasomes
Inflammation
Plaque, Atherosclerotic
Stroke - drug therapy
atherosclerosis
NLRP
therapies
Inflammasomes
inflammation
stroke
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Abstract Inflammation is a devastating outcome of cerebrovascular diseases (CVD), namely stroke and atherosclerosis. Numerous studies over the decade have shown that inflammasomes play a role in mediating inflammatory reactions post cellular injury occurring after a stroke or a rupture of an atherosclerotic plaque. In view of this, targeting these inflammatory pathways using different pharmacological therapies may improve outcomes in patients with CVD. Here, we review the mechanisms by which inflammasomes drive the pathogenesis of stroke and atherosclerosis. Also, discussed here are the possible treatment strategies available for inhibiting inflammasomes or their up-stream/down-stream mediators.
AbstractList Inflammation is a devastating outcome of cerebrovascular diseases (CVD), namely stroke and atherosclerosis. Numerous studies over the decade have shown that inflammasomes play a role in mediating inflammatory reactions post cellular injury occurring after a stroke or a rupture of an atherosclerotic plaque. In view of this, targeting these inflammatory pathways using different pharmacological therapies may improve outcomes in patients with CVD. Here, we review the mechanisms by which inflammasomes drive the pathogenesis of stroke and atherosclerosis. Also, discussed here are the possible treatment strategies available for inhibiting inflammasomes or their up-stream/down-stream mediators.
Author Raut, Swapnil
Sarkar, Ankan
Shah, Birva
Wang, Xin
Dave, Kunjan R
Sarmah, Deepaneeta
Baidya, Falguni
Kalia, Kiran
Bhattacharya, Pallab
Yavagal, Dileep R
Bohra, Mariya
Datta, Aishika
Singh, Upasna
Jagtap, Priya
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  organization: Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India
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  givenname: Aishika
  surname: Datta
  fullname: Datta, Aishika
  organization: Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India
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  givenname: Swapnil
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  organization: Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India
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  givenname: Ankan
  surname: Sarkar
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  organization: Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India
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  organization: Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India
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  givenname: Mariya
  surname: Bohra
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  givenname: Upasna
  surname: Singh
  fullname: Singh, Upasna
  organization: Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India
– sequence: 8
  givenname: Priya
  surname: Jagtap
  fullname: Jagtap, Priya
  organization: Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India
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  givenname: Falguni
  surname: Baidya
  fullname: Baidya, Falguni
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  givenname: Kiran
  surname: Kalia
  fullname: Kalia, Kiran
  organization: Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India
– sequence: 11
  givenname: Xin
  surname: Wang
  fullname: Wang, Xin
  organization: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, United States
– sequence: 12
  givenname: Kunjan R
  surname: Dave
  fullname: Dave, Kunjan R
  organization: Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, United States
– sequence: 13
  givenname: Dileep R
  surname: Yavagal
  fullname: Yavagal, Dileep R
  organization: Department of Neurology and Neurosurgery, University of Miami Miller School of Medicine, Miami, Florida, United States
– sequence: 14
  givenname: Pallab
  surname: Bhattacharya
  fullname: Bhattacharya, Pallab
  organization: Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India
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Issue 34
Keywords atherosclerosis
NLRP
therapies
Inflammasomes
inflammation
stroke
Language English
License Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
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Snippet Inflammation is a devastating outcome of cerebrovascular diseases (CVD), namely stroke and atherosclerosis. Numerous studies over the decade have shown that...
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StartPage 4234
SubjectTerms Atherosclerosis - drug therapy
Humans
Inflammasomes
Inflammation
Plaque, Atherosclerotic
Stroke - drug therapy
Title The Role of Inflammasomes in Atherosclerosis and Stroke Pathogenesis
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Volume 26
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