The Role of Inflammasomes in Atherosclerosis and Stroke Pathogenesis

Inflammation is a devastating outcome of cerebrovascular diseases (CVD), namely stroke and atherosclerosis. Numerous studies over the decade have shown that inflammasomes play a role in mediating inflammatory reactions post cellular injury occurring after a stroke or a rupture of an atherosclerotic...

Full description

Saved in:
Bibliographic Details
Published inCurrent pharmaceutical design Vol. 26; no. 34; p. 4234
Main Authors Sarmah, Deepaneeta, Datta, Aishika, Raut, Swapnil, Sarkar, Ankan, Shah, Birva, Bohra, Mariya, Singh, Upasna, Jagtap, Priya, Baidya, Falguni, Kalia, Kiran, Wang, Xin, Dave, Kunjan R, Yavagal, Dileep R, Bhattacharya, Pallab
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2020
Subjects
Atherosclerosis - drug therapy
Humans
Inflammasomes
Inflammation
Plaque, Atherosclerotic
Stroke - drug therapy
atherosclerosis
NLRP
therapies
Inflammasomes
inflammation
stroke
Online AccessGet more information

Cover

More Information
Summary:Inflammation is a devastating outcome of cerebrovascular diseases (CVD), namely stroke and atherosclerosis. Numerous studies over the decade have shown that inflammasomes play a role in mediating inflammatory reactions post cellular injury occurring after a stroke or a rupture of an atherosclerotic plaque. In view of this, targeting these inflammatory pathways using different pharmacological therapies may improve outcomes in patients with CVD. Here, we review the mechanisms by which inflammasomes drive the pathogenesis of stroke and atherosclerosis. Also, discussed here are the possible treatment strategies available for inhibiting inflammasomes or their up-stream/down-stream mediators.
ISSN:1873-4286
DOI:10.2174/1381612826666200427084949