Diabetes and Complications: Cellular Signaling Pathways, Current Understanding and Targeted Therapies

Diabetes is a metabolic disorder and over the past decades, it has become a major cause of morbidity and mortality affecting the youth and middle-aged as it is the fourth leading cause of disease related to death. In both type 1 and type 2 diabetes the severe pathogenesis cause micro vascular compli...

Full description

Saved in:
Bibliographic Details
Published inCurrent drug targets Vol. 17; no. 11; p. 1309
Main Authors Adeshara, Krishna A, Diwan, Arundhati G, Tupe, Rashmi S
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.09.2016
Subjects
Online AccessGet more information

Cover

Loading…
Abstract Diabetes is a metabolic disorder and over the past decades, it has become a major cause of morbidity and mortality affecting the youth and middle-aged as it is the fourth leading cause of disease related to death. In both type 1 and type 2 diabetes the severe pathogenesis cause micro vascular complications: nephropathy, retinopathy, neuropathy and macro vascular complications: cardiovascular disease, heart attacks and stroke. Under hyperglycemia, activation of different signaling mechanisms such as an increased polyol pathway, advanced-glycation end product formation, activation of Protein Kinase C and hexosamine pathway leads to the over expression of reactive oxygen species and causes pathogenesis of diabetic complications. It is necessary to understand these pathways in diabetic complications causing damage to the secondary system of the body. In the past decade the understanding of these biochemical changes has increased tremendously and various molecules have been exploited as therapeutic targets for diabetic complications as better therapeutic approach. In this review, a brief overview about diabetes mellitus and chronic complications with their current understandings of cellular/molecular mechanisms and targeted therapies along with novel therapeutic strategies is discussed.
AbstractList Diabetes is a metabolic disorder and over the past decades, it has become a major cause of morbidity and mortality affecting the youth and middle-aged as it is the fourth leading cause of disease related to death. In both type 1 and type 2 diabetes the severe pathogenesis cause micro vascular complications: nephropathy, retinopathy, neuropathy and macro vascular complications: cardiovascular disease, heart attacks and stroke. Under hyperglycemia, activation of different signaling mechanisms such as an increased polyol pathway, advanced-glycation end product formation, activation of Protein Kinase C and hexosamine pathway leads to the over expression of reactive oxygen species and causes pathogenesis of diabetic complications. It is necessary to understand these pathways in diabetic complications causing damage to the secondary system of the body. In the past decade the understanding of these biochemical changes has increased tremendously and various molecules have been exploited as therapeutic targets for diabetic complications as better therapeutic approach. In this review, a brief overview about diabetes mellitus and chronic complications with their current understandings of cellular/molecular mechanisms and targeted therapies along with novel therapeutic strategies is discussed.
Author Adeshara, Krishna A
Tupe, Rashmi S
Diwan, Arundhati G
Author_xml – sequence: 1
  givenname: Krishna A
  surname: Adeshara
  fullname: Adeshara, Krishna A
– sequence: 2
  givenname: Arundhati G
  surname: Diwan
  fullname: Diwan, Arundhati G
– sequence: 3
  givenname: Rashmi S
  surname: Tupe
  fullname: Tupe, Rashmi S
  email: rashmitupe@gmail.com
  organization: Biochemical Sciences Division, Rajiv Gandhi Institute of IT and Biotechnology, Bharati Vidyapeeth University, Pune-411 046, India. rashmitupe@gmail.com
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26648059$$D View this record in MEDLINE/PubMed
BookMark eNo1j11LwzAYhYMoOqd_QeK91Xyn9U46v2Cg4HY93ibvtkCblrRF9u_tUK_OgcPzwLkkp7GNSMgtZ_eCW_XAZV4ozTi3xhiuuWAFF4oxe0JmPLcy07oQ5-RCGKNyposZwUWACgfsKURPy7bp6uBgCG3sH2mJdT3WkOhX2EWoQ9zRTxj233Do72g5poRxoOvoMfXDhB_3o2UFaTcpp7LHBF3A_oqcbaHu8fov52T98rwq37Llx-t7-bTMKqXUkKkKBIA3zOfaC2akVVZWhQWNleMSndNbdCZXzHqlmLdomXBSwtYwx7kUc3Lz6-3GqkG_6VJoIB02_3_FD9s0V8c
CitedBy_id crossref_primary_10_1016_j_lfs_2021_120184
crossref_primary_10_2337_db23_0807
crossref_primary_10_3390_medicina58111604
crossref_primary_10_1007_s00580_021_03284_3
crossref_primary_10_1016_j_lfs_2020_118145
crossref_primary_10_3892_mmr_2018_9412
crossref_primary_10_1016_j_heliyon_2019_e01986
crossref_primary_10_1007_s11101_024_09946_8
crossref_primary_10_1007_s12010_021_03661_2
crossref_primary_10_1111_jfbc_13846
crossref_primary_10_1016_j_biopha_2016_12_059
crossref_primary_10_1007_s12325_021_01791_x
crossref_primary_10_1016_j_inffus_2021_02_015
crossref_primary_10_3389_fphar_2022_1031051
crossref_primary_10_1051_bmdcn_2017070201
crossref_primary_10_1111_jcmm_17787
crossref_primary_10_1080_13880209_2016_1228683
crossref_primary_10_2174_1573399815666181204145806
crossref_primary_10_1002_app_48037
crossref_primary_10_1002_jcp_28425
crossref_primary_10_1186_s12951_024_02616_z
crossref_primary_10_1016_j_jdiacomp_2016_10_012
crossref_primary_10_1038_s41598_017_09641_z
crossref_primary_10_14503_THIJ_22_7873
crossref_primary_10_1016_j_jocs_2020_101186
crossref_primary_10_1007_s43450_021_00175_0
crossref_primary_10_18632_aging_202217
crossref_primary_10_1016_j_coph_2018_07_011
crossref_primary_10_1139_apnm_2017_0461
crossref_primary_10_3892_etm_2018_6152
crossref_primary_10_1155_2021_8832114
crossref_primary_10_1016_j_jfo_2023_01_024
crossref_primary_10_1080_13813455_2019_1623820
crossref_primary_10_1007_s12576_019_00696_3
crossref_primary_10_1016_j_cjca_2017_12_005
crossref_primary_10_1016_j_lfs_2019_116957
crossref_primary_10_1038_s41598_024_61011_8
crossref_primary_10_1016_j_yexcr_2020_111849
crossref_primary_10_1093_glycob_cwac060
crossref_primary_10_1080_13813455_2020_1811731
crossref_primary_10_1002_jcp_30878
crossref_primary_10_1007_s11062_019_09816_6
crossref_primary_10_1111_joim_12562
crossref_primary_10_47705_kjdmr_237212
crossref_primary_10_1515_med_2023_0683
crossref_primary_10_3892_ijmm_2021_5062
crossref_primary_10_3892_mmr_2023_13136
crossref_primary_10_3390_molecules28207202
crossref_primary_10_1186_s12882_020_01833_6
crossref_primary_10_18632_oncotarget_24916
crossref_primary_10_2174_1566523219666190925112249
crossref_primary_10_1016_j_ijbiomac_2019_09_118
ContentType Journal Article
DBID CGR
CUY
CVF
ECM
EIF
NPM
DOI 10.2174/1389450117666151209124007
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
DatabaseTitleList MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod no_fulltext_linktorsrc
EISSN 1873-5592
ExternalDocumentID 26648059
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GroupedDBID CGR
CUY
CVF
ECM
EIF
NPM
ID FETCH-LOGICAL-b444t-4ba2aad60d85d20637473b97a5ebc13ecc5fec68407d440d7e702c33af60c1132
IngestDate Tue Jul 04 17:41:45 EDT 2023
IsPeerReviewed true
IsScholarly true
Issue 11
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-b444t-4ba2aad60d85d20637473b97a5ebc13ecc5fec68407d440d7e702c33af60c1132
PMID 26648059
ParticipantIDs pubmed_primary_26648059
PublicationCentury 2000
PublicationDate 2016-09-01
PublicationDateYYYYMMDD 2016-09-01
PublicationDate_xml – month: 09
  year: 2016
  text: 2016-09-01
  day: 01
PublicationDecade 2010
PublicationPlace United Arab Emirates
PublicationPlace_xml – name: United Arab Emirates
PublicationTitle Current drug targets
PublicationTitleAlternate Curr Drug Targets
PublicationYear 2016
Score 2.4506674
SecondaryResourceType review_article
Snippet Diabetes is a metabolic disorder and over the past decades, it has become a major cause of morbidity and mortality affecting the youth and middle-aged as it is...
SourceID pubmed
SourceType Index Database
StartPage 1309
SubjectTerms Animals
Diabetes Complications - physiopathology
Diabetes Complications - therapy
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - physiopathology
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - physiopathology
Glycation End Products, Advanced - metabolism
Humans
Molecular Targeted Therapy
Reactive Oxygen Species - metabolism
Signal Transduction
Title Diabetes and Complications: Cellular Signaling Pathways, Current Understanding and Targeted Therapies
URI https://www.ncbi.nlm.nih.gov/pubmed/26648059
Volume 17
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Ra9swEBbpBqUvY2Nru3UbGuxtdWtbkuXsLaQbZdBSWgf6ViRLSlJaL6QJhf6A_u7d2ZZjl5Z1ezHBioXQ9-n03fl0JuSrzBPH-ywJYPfjATexDjAyGBhujMilM6HDg8JHx8nhiP86F-e93n0ra2m50Hv53aPnSv4HVbgHuOIp2X9AtukUbsBvwBeugDBcn4XxgQ-cYvR72E4OR0d_aK-uyiTTs-kY5XYxxoL8k1tVYecrM406x1uwp6zMDgclmpWHs3ya4WW3TqmZL8ffqkTyRpcPDL5BmitvPiaFWgVLD6a3VbR1MF8WZgIDXX3YK1vOysjqqbqZXE_reGwdjIiSJtsK9pLKgKaSBeCldC2sbDMpatlL2EH7jxlydJQwpgByigssWwdeFmoTUDeY9Crbz8CMzq5LhEFs8DQU_b-3Pqix7ZvWyJpM0Voenxytky_1QPafHAaWkq4ffeCWlPIke01e1X4FHVQkeUN6tnhLrCcIBVhphyDfqacHbehBPT12aQ0y7ZCj7MWTgzbkeEdGP39kw8Og_q5GoDnni4BrFStlktCkwsSgUcGlZLovlbA6jxgsauFsjlWApOE8NNLKMM4ZUy4J8yhi8SZ5Ufwu7DahUgprBNeRhb_Dyk4dE84ZFyue6pC592SrmpWLWVU85cLP14cnW3bIxopaH8lLB6vVfgLpt9CfS2T-AM4KWbw
link.rule.ids 783
linkProvider National Library of Medicine
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Diabetes+and+Complications%3A+Cellular+Signaling+Pathways%2C+Current+Understanding+and+Targeted+Therapies&rft.jtitle=Current+drug+targets&rft.au=Adeshara%2C+Krishna+A&rft.au=Diwan%2C+Arundhati+G&rft.au=Tupe%2C+Rashmi+S&rft.date=2016-09-01&rft.eissn=1873-5592&rft.volume=17&rft.issue=11&rft.spage=1309&rft_id=info:doi/10.2174%2F1389450117666151209124007&rft_id=info%3Apmid%2F26648059&rft_id=info%3Apmid%2F26648059&rft.externalDocID=26648059