PErsonalized TReatment for Endometrial Carcinoma (PETREC): study design and methods of a prospective Finnish multicenter trial

• Published in: International journal of gynecological cancer Vol. 33; no. 11; pp. 1807 - 1811
• Main Authors: Loukovaara, Mikko, Bützow, Ralf, Staff, Synnöve, Mäenpää, Minna, Faltinová, Mária, Lassus, Heini, Veijalainen, Olga, Grönvall, Maiju, Vaalavirta, Leila, Kuikka, Elina, Haataja, Marjut, Urpilainen, Elina, Simojoki, Marja, Anttila, Maarit, Auranen, Annika
• Format: Journal Article
• Language: English
• Published: United States BMJ Publishing Group Ltd 01.11.2023; Elsevier Inc; Elsevier Limited
• Subjects: Cancer therapies; Carcinoma - pathology; Chemotherapy; Clinical trial; Endometrial cancer; Endometrial Neoplasms - pathology; Endometrium; Female; Finland; Gynecology; Humans; Hysterectomy; Neoplasm Recurrence, Local - pathology; Neoplasm Staging; Obstetrics; Oncology; Oophorectomy; Pathology; Patients; Precision Medicine; Prospective Studies; Quality of life; Radiation therapy; Retrospective Studies; Society; Surgery; Toxicity; Tumors; Uterine Cancer; Vagina; Yeast; Finland; Uterine Cancer; Endometrium

BackgroundEndometrial carcinomas can be classified into four molecular subgroups – mismatch repair deficient (MMRd), p53 abnormal (p53abn), polymerase-ϵ (POLE) ultramutated, and ‘no specific molecular profile’ (NSMP). Retrospective data imply that the response to adjuvant therapies may depend on the...