Dual Inhibition of Cdc7 and Cdk9 by PHA-767491 Suppresses Hepatocarcinoma Synergistically with 5-Fluorouracil - Li, Wei; Zhao, Xiao-Le; Shang, Shi-Qiang; Shen, Hong-Qiang; Chen, Xi (Current cancer drug targets, 2015)
Keywords: Animals; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - metabolism; Cell Cycle Proteins - antagonists & inhibitors; Cell Cycle Proteins - metabolism; Cell Line, Tumor - drug effects; Checkpoint Kinase 1; Cyclin-Dependent Kinase 9 - antagonists & inhibitors; Cyclin-Dependent Kinase 9 - metabolism; Female; Fluorouracil - administration & dosage; Humans; Liver Neoplasms - drug therapy; Liver Neoplasms - metabolism; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy - methods; Myeloid Cell Leukemia Sequence 1 Protein - genetics; Myeloid Cell Leukemia Sequence 1 Protein - metabolism; Phosphorylation - drug effects; Piperidones - administration & dosage; Piperidones - pharmacology; Protein Kinase Inhibitors - pharmacology; Protein Kinases - metabolism; Protein-Serine-Threonine Kinases - antagonists & inhibitors; Protein-Serine-Threonine Kinases - metabolism; Pyrroles - administration & dosage; Pyrroles - pharmacology; Xenograft Model Antitumor Assays