Influence of glycation of plasma proteins in diabetes on the binding interaction with polyphenols

Diabetes mellitus is one of the most serious diseases in the world. The degree of glycated plasma proteins is increased in diabetics compared to non-diabetic subjects. This mini-review focuses on the influence of glycation of human serum albumin (HSA) in diabetes on the binding interaction with diet...

Full description

Saved in:
Bibliographic Details
Published inCurrent drug metabolism Vol. 15; no. 1; p. 116
Main Authors Xu, Wei, Chen, Longsheng, Shao, Rong
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2014
Subjects
Diabetes Mellitus - metabolism
Glycosylation
Humans
Polyphenols - pharmacokinetics
Protein Binding
Serum Albumin - metabolism
Online AccessGet more information

Cover

Abstract Diabetes mellitus is one of the most serious diseases in the world. The degree of glycated plasma proteins is increased in diabetics compared to non-diabetic subjects. This mini-review focuses on the influence of glycation of human serum albumin (HSA) in diabetes on the binding interaction with dietary polyphenols. The non-enzymatic glycation of HSA leads to a conformational change in HSA, which in turn influences the ligand binding properties. HSA glycation is believed to reduce the binding affinities for acidic drugs such as dietary polyphenols and phenolic acids.
AbstractList Diabetes mellitus is one of the most serious diseases in the world. The degree of glycated plasma proteins is increased in diabetics compared to non-diabetic subjects. This mini-review focuses on the influence of glycation of human serum albumin (HSA) in diabetes on the binding interaction with dietary polyphenols. The non-enzymatic glycation of HSA leads to a conformational change in HSA, which in turn influences the ligand binding properties. HSA glycation is believed to reduce the binding affinities for acidic drugs such as dietary polyphenols and phenolic acids.
Author Chen, Longsheng
Shao, Rong
Xu, Wei
Author_xml – sequence: 1
  givenname: Wei
  surname: Xu
  fullname: Xu, Wei
– sequence: 2
  givenname: Longsheng
  surname: Chen
  fullname: Chen, Longsheng
– sequence: 3
  givenname: Rong
  surname: Shao
  fullname: Shao, Rong
  email: sr@ycit.cn
  organization: School of Chemical and Biological Engineering, Yancheng Institute of Technology, 224051 Yancheng, China. sr@ycit.cn
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24479686$$D View this record in MEDLINE/PubMed
BookMark eNo1j91KxDAUhIMouq6-gsQHqOacJk16KYuuCwve6PWSNCfbQJuWNovs27v-XQ3DfDMw1-w8DYkYuwfxgKDlI5SmRiEQVFVVIAWUAiQYLM_YAoxWhZKqvGRXKKWuK1MtmN2k0B0oNcSHwPfdsbE5DunbjJ2de8vHacgU08xj4j5aR5lmfiJyS9zF5GPan6JMk21-mp8xt3wcuuPYUhq6-YZdBNvNdPunS_bx8vy-ei22b-vN6mlbOCkxF1g5D4EaYwwZGQxq570ismictqKRGCTWJYlaB4XS1TYA1o7QG7CgGlyyu9_d8eB68rtxir2djrv_r_gFvMhXXQ
CitedBy_id crossref_primary_10_1016_j_nutres_2015_05_003
crossref_primary_10_1016_j_talanta_2014_11_061
crossref_primary_10_1039_C6RA08283A
ContentType Journal Article
DBID CGR
CUY
CVF
ECM
EIF
NPM
DOI 10.2174/1389200215666140130141823
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
DatabaseTitleList MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod no_fulltext_linktorsrc
EISSN 1875-5453
ExternalDocumentID 24479686
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GroupedDBID CGR
CUY
CVF
ECM
EIF
NPM
ID FETCH-LOGICAL-b442t-26bd1fec888e84f827bdd5eea28b7a0c42f4293e097f524b9af129be2d81a15c2
IngestDate Tue Jul 04 17:17:53 EDT 2023
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-b442t-26bd1fec888e84f827bdd5eea28b7a0c42f4293e097f524b9af129be2d81a15c2
PMID 24479686
ParticipantIDs pubmed_primary_24479686
PublicationCentury 2000
PublicationDate 2014-01-01
PublicationDateYYYYMMDD 2014-01-01
PublicationDate_xml – month: 01
  year: 2014
  text: 2014-01-01
  day: 01
PublicationDecade 2010
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle Current drug metabolism
PublicationTitleAlternate Curr Drug Metab
PublicationYear 2014
Score 2.0733905
SecondaryResourceType review_article
Snippet Diabetes mellitus is one of the most serious diseases in the world. The degree of glycated plasma proteins is increased in diabetics compared to non-diabetic...
SourceID pubmed
SourceType Index Database
StartPage 116
SubjectTerms Diabetes Mellitus - metabolism
Glycosylation
Humans
Polyphenols - pharmacokinetics
Protein Binding
Serum Albumin - metabolism
Title Influence of glycation of plasma proteins in diabetes on the binding interaction with polyphenols
URI https://www.ncbi.nlm.nih.gov/pubmed/24479686
Volume 15
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bS8MwFA5eQHwRxfuNCL6N6pombfoooqg48WGDvY2kTeZga4fOh_nrPUnark7Fy0vpkq6Unu8cvnN6LgidpkwIpkPf00QGHk1A02MFXgpvhjJlsZ8wG9BvPYQ3HXrXZd1ZWpGtLpnIs-Tty7qS_0gV1kCupkr2D5KtbgoLcA7yhSNIGI6_kvFtOWHEUL7-cJpU_G8MpHgkGrYLw8DlildRVvd5oCEHZUGLKUJ2E8NtVHacD6cm8ysfvtSpa9nJKX1-7ZvB04CeYdl_ECTWfbXpemowSxhwFu0-z_ovcN6vgjlPIndJ3cVaEXTwaS3ooJyhBD_HA_YVfLCk7BNinFn0XT3lvLk27pCJHABpsrkiQC1D6_CZ7FPu6pBrYhyPrByBkERxyMOfd-c6aZdbi2gRfAozJPWxtYJOigc5__YxTMPo4q9zzoclIe11tFZ4D_jCQWEDLahsE4kKBjjXuIKB-eFggEsY4EGGSxhguAJggAsY4BoMsIEBrsFgC3Wur9qXN14xOcOTlJKJR0DRfK0SzrniVHMSyTRlSgnCZSSaCSUaeEigmnGkGaEyFhp4n1Qk5b7wWUK20VKWZ2oXYWYGCigWBRGTFPRaEqA3VCpQcOHHKthDO-6N9MauPUqvfFf73-4coNUZqA7RsgZ9VEdA7iby2ErlHdEoUD4
linkProvider National Library of Medicine
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Influence+of+glycation+of+plasma+proteins+in+diabetes+on+the+binding+interaction+with+polyphenols&rft.jtitle=Current+drug+metabolism&rft.au=Xu%2C+Wei&rft.au=Chen%2C+Longsheng&rft.au=Shao%2C+Rong&rft.date=2014-01-01&rft.eissn=1875-5453&rft.volume=15&rft.issue=1&rft.spage=116&rft_id=info:doi/10.2174%2F1389200215666140130141823&rft_id=info%3Apmid%2F24479686&rft_id=info%3Apmid%2F24479686&rft.externalDocID=24479686