Intravenous Tranexamic Acid for Brain Contusion with Intraparenchymal Hemorrhage: Randomized, Double-Blind, Placebo-Controlled Trial
Controlling of secondary traumatic brain injuries (TBI) is necessary due to its salient effect on the improvement of patients with TBI and the final outcomes within early hours of trauma onset. This study aims to investigate the effect of intravenous tranexamic acid (TAX) administration on decreased...
Saved in:
Published in | Reviews on recent clinical trials Vol. 15; no. 1; p. 70 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United Arab Emirates
01.01.2020
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | Controlling of secondary traumatic brain injuries (TBI) is necessary due to its salient effect on the improvement of patients with TBI and the final outcomes within early hours of trauma onset. This study aims to investigate the effect of intravenous tranexamic acid (TAX) administration on decreased hemorrhage during surgery.
This double-blind, randomized, and placebo-controlled trial was conducted on patients referring to the emergency department (ED) with IPH due to brain contusion within 8 h of injury onset. The patients were evaluated by receiving TXA and 0.9% normal saline as a placebo. The following evaluation and estimations were performed: intracranial hemorrhage volume after surgery using brain CT-scan; hemoglobin (Hb) volume before, immediately after, and six hours after surgery; and the severity of TBI based on Glasgow Coma Score (GCS).
40 patients with 55.02 ± 18.64 years old diagnosed with a contusion and intraparenchymal hemorrhage. Although the (Mean ± SD) hemorrhage during surgery in patients receiving TXA (784.21 ± 304.162) was lower than the placebo group (805.26 ± 300.876), no significant difference was observed between two groups (P=0.83). The (Mean ± SD) Hb volume reduction immediately during surgery (0.07 ± 0.001 and 0.23 ± 0.02) and six hours after surgery (0.04 ± 0.008 and 0.12 ± 0.006) was also lower in TXA group but had no significant difference (P = 0.89 and P = 0.97, respectively).
Using TXA may reduce the hemorrhage in patients with TBI, but this effect, as in this study, was not statistically significant and it is suggested that a clinical trial with a larger population is employed for further investigation. |
---|---|
AbstractList | Controlling of secondary traumatic brain injuries (TBI) is necessary due to its salient effect on the improvement of patients with TBI and the final outcomes within early hours of trauma onset. This study aims to investigate the effect of intravenous tranexamic acid (TAX) administration on decreased hemorrhage during surgery.
This double-blind, randomized, and placebo-controlled trial was conducted on patients referring to the emergency department (ED) with IPH due to brain contusion within 8 h of injury onset. The patients were evaluated by receiving TXA and 0.9% normal saline as a placebo. The following evaluation and estimations were performed: intracranial hemorrhage volume after surgery using brain CT-scan; hemoglobin (Hb) volume before, immediately after, and six hours after surgery; and the severity of TBI based on Glasgow Coma Score (GCS).
40 patients with 55.02 ± 18.64 years old diagnosed with a contusion and intraparenchymal hemorrhage. Although the (Mean ± SD) hemorrhage during surgery in patients receiving TXA (784.21 ± 304.162) was lower than the placebo group (805.26 ± 300.876), no significant difference was observed between two groups (P=0.83). The (Mean ± SD) Hb volume reduction immediately during surgery (0.07 ± 0.001 and 0.23 ± 0.02) and six hours after surgery (0.04 ± 0.008 and 0.12 ± 0.006) was also lower in TXA group but had no significant difference (P = 0.89 and P = 0.97, respectively).
Using TXA may reduce the hemorrhage in patients with TBI, but this effect, as in this study, was not statistically significant and it is suggested that a clinical trial with a larger population is employed for further investigation. |
Author | Ilkhchi, Reza Bahrami Ebrahimi, Pouya Mousavinejad, Maryam Mozafari, Javad Hanafi, Mohammad Ghasem |
Author_xml | – sequence: 1 givenname: Maryam surname: Mousavinejad fullname: Mousavinejad, Maryam organization: Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran – sequence: 2 givenname: Javad surname: Mozafari fullname: Mozafari, Javad organization: Department of Emergency Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran – sequence: 3 givenname: Reza Bahrami surname: Ilkhchi fullname: Ilkhchi, Reza Bahrami organization: Department of Neurosurgery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran – sequence: 4 givenname: Mohammad Ghasem surname: Hanafi fullname: Hanafi, Mohammad Ghasem organization: Department of Radiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran – sequence: 5 givenname: Pouya surname: Ebrahimi fullname: Ebrahimi, Pouya organization: Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31744452$$D View this record in MEDLINE/PubMed |
BookMark | eNo1UMlOwzAUtBCIpfALyNwJ-LmJ43Bry9JKlUConKvnJdSSY1duApQzH07KchiN3mhmnjQnZD_EYAm5AHbFocyvoShzKUuAXAgBFQDIHbjYI8cgS5EBG8pDcjTszXle8GPyNQttwjcbYrehi4TBfmDjNB1pZ2gdEx0ndIFOYmi7jYuBvrt2RX9Ca0w26NW2QU-ntokprfDV3tBnDCY27tOaS3obO-VtNvYu9NeTR21VzHZtKXpvTf_SoT8lBzX6jT374wF5ub9bTKbZ_PFhNhnNM5Xn0GZGIjBkNRNGcGk442ooesGYoigqpqwqmIKq0spIEBUWWpVVrSW3WhspOR-Q89_edacaa5br5BpM2-X_HPwb0C9jSA |
CitedBy_id | crossref_primary_10_1016_j_redar_2023_04_005 crossref_primary_10_1016_j_jstrokecerebrovasdis_2020_105436 crossref_primary_10_1016_j_ajem_2024_03_005 crossref_primary_10_1227_neu_0000000000002961 crossref_primary_10_1016_j_ajem_2022_03_027 crossref_primary_10_1186_s13049_024_01188_z crossref_primary_10_1093_neuros_nyaa545 crossref_primary_10_1186_s12883_020_01694_4 crossref_primary_10_1007_s00134_020_06279_w crossref_primary_10_1016_j_redare_2024_02_013 crossref_primary_10_1097_ACO_0000000000001171 crossref_primary_10_1186_s12959_022_00440_9 crossref_primary_10_1371_journal_pone_0282726 |
ContentType | Journal Article |
Copyright | Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. |
Copyright_xml | – notice: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.2174/1574887114666191118111826 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
EISSN | 1876-1038 |
ExternalDocumentID | 31744452 |
Genre | Clinical Trial Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | CGR CUY CVF ECM EIF NPM |
ID | FETCH-LOGICAL-b441t-d8a10a0f06d628d202b360a0dd55590beb50b199cbd8169a5cb79fc82eccd8822 |
IngestDate | Sat Sep 18 00:43:01 EDT 2021 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Keywords | trauma intraparenchymal hemorrhage linical trial study emergency medicine Cerebral hemorrhage tranexamic acid |
Language | English |
License | Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-b441t-d8a10a0f06d628d202b360a0dd55590beb50b199cbd8169a5cb79fc82eccd8822 |
PMID | 31744452 |
ParticipantIDs | pubmed_primary_31744452 |
PublicationCentury | 2000 |
PublicationDate | 2020-01-01 |
PublicationDateYYYYMMDD | 2020-01-01 |
PublicationDate_xml | – month: 01 year: 2020 text: 2020-01-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | United Arab Emirates |
PublicationPlace_xml | – name: United Arab Emirates |
PublicationTitle | Reviews on recent clinical trials |
PublicationTitleAlternate | Rev Recent Clin Trials |
PublicationYear | 2020 |
Score | 2.2836776 |
Snippet | Controlling of secondary traumatic brain injuries (TBI) is necessary due to its salient effect on the improvement of patients with TBI and the final outcomes... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 70 |
SubjectTerms | Adult Aged Antifibrinolytic Agents - administration & dosage Blood Loss, Surgical - prevention & control Brain Contusion - complications Brain Contusion - drug therapy Brain Contusion - surgery Brain Hemorrhage, Traumatic - etiology Brain Hemorrhage, Traumatic - mortality Brain Hemorrhage, Traumatic - prevention & control Double-Blind Method Female Glasgow Coma Scale Humans Infusions, Intravenous Male Middle Aged Survival Rate Tranexamic Acid - administration & dosage Treatment Outcome |
Title | Intravenous Tranexamic Acid for Brain Contusion with Intraparenchymal Hemorrhage: Randomized, Double-Blind, Placebo-Controlled Trial |
URI | https://www.ncbi.nlm.nih.gov/pubmed/31744452 |
Volume | 15 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF6lIFW9VCDeBbRI3NIF2_GTW1MBpZIrDqnUWzXr3ZULsV1FaURz5j_yd5jZTWyTUgRcLGtXG9k7X2a_Gc-DsddSxibBSZFF4UiEcZqJFMJUREjtESEmGNkSG_lJfHQaHp9FZ4PBj17U0tVcvimWv80r-R-p4hjKlbJk_0Gy7Y_iAN6jfPGKEsbrX8n4E3lmF67KKh06-ht1lx8eFBfKhg-Oqf8DJfXNr8gp5pyudhHFnddFeV3Z2sJVM5uVqFhsdBzUqqkuls4JivxaTrUYIxl1hJO87rIRhy7CfYp0dUIv2ue47nOD_QyB6pRiDdr0S9sjpGXxOT43LJDmfnE4y2F2DVU3uwQDLhH-GBagWhRPv5aF7UWM4FjCcAzlDN-706U1GDubNyVUFajhxxLP6qrv4Ai8noNDO6WMGltQIfdftHZ0A51OBbs-JJsnA1le5KSIEtRYCaViIzEhRZ_61sTqr8HNvqwsZJBchWHoSuz-eXajaPd6aottJSkp3pPP-TZ7tXqQt7c-xg7bXi_dsHMs35ncY7srQ4UfONTdZwNdP2Dfe4jjHeI4IY4j4rhFHG8RxwlxfBNxvEPcO97hbZ_30bbPb2KNW6w9ZKcf3k8Oj8Sqj4eQSLbnQqXge-AZL1ZxkCqUsRzFOKBUhPasJ7WMPOlnWSFV6scZRIVMMlOkAaoXhRZg8IjdqZtaP2Fc-1CgjWIylUAYaQOBH1MFp1gbWfhaP2WP3aadX7piLefr7Xx268we2-lg95zdNfhH0C-Qas7lSyu4n9hvgnM |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Intravenous+Tranexamic+Acid+for+Brain+Contusion+with+Intraparenchymal+Hemorrhage%3A+Randomized%2C+Double-Blind%2C+Placebo-Controlled+Trial&rft.jtitle=Reviews+on+recent+clinical+trials&rft.au=Mousavinejad%2C+Maryam&rft.au=Mozafari%2C+Javad&rft.au=Ilkhchi%2C+Reza+Bahrami&rft.au=Hanafi%2C+Mohammad+Ghasem&rft.date=2020-01-01&rft.eissn=1876-1038&rft.volume=15&rft.issue=1&rft.spage=70&rft_id=info:doi/10.2174%2F1574887114666191118111826&rft_id=info%3Apmid%2F31744452&rft_id=info%3Apmid%2F31744452&rft.externalDocID=31744452 |