The protein-protein interaction-mediated inactivation of PTEN

• Published in: Current molecular medicine Vol. 14; no. 1; p. 22
• Main Authors: De Melo, J, He, L, Tang, D
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2014
• Subjects: Animals; Carrier Proteins - chemistry; Carrier Proteins - metabolism; Enzyme Activation; Humans; Protein Binding; Protein Interaction Domains and Motifs; PTEN Phosphohydrolase - chemistry; PTEN Phosphohydrolase - metabolism

PTEN (Phosphatase and Tensin homologue deleted on chromosome 10, 10q23.3) is the dominant phosphatase responsible for the dephosphorylation of the 3-position phosphate from the inositol ring of phosphatidylinositol 3,4,5 triphosphate (PIP3), and thereby directly antagonizes the actions mediated by P...