Modulation of p53 activity by I Kappa B alpha : Evidence suggesting a common phylogeny between NF- Kappa B and p53 transcription factors

• Published in: BMC immunology Vol. 6; no. 1; p. 12
• Main Authors: Dreyfus, David H, Nagasawa, Masayuki, Gelfand, Erwin W, Ghoda, Lucy Y
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 21.06.2005; BioMed Central; BMC

In this work we present evidence that the p53 tumor suppressor protein and NF- Kappa B transcription factors could be related through common descent from a family of ancestral transcription factors regulating cellular proliferation and apoptosis. P53 is a homotetrameric transcription factor known to...