Tau-PET imaging predicts cognitive decline and brain atrophy progression in early Alzheimer’s disease

• Published in: Journal of neurology, neurosurgery and psychiatry Vol. 93; no. 5; pp. 459 - 467
• Main Authors: Lagarde, Julien, Olivieri, Pauline, Tonietto, Matteo, Tissot, Cecile, Rivals, Isabelle, Gervais, Philippe, Caillé, Fabien, Moussion, Martin, Bottlaender, Michel, Sarazin, Marie
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd 01.05.2022; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Alzheimer Disease - cerebrospinal fluid; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Atrophy; Biomarkers; Biomarkers - cerebrospinal fluid; Brain - diagnostic imaging; Brain - metabolism; Brain research; Cognition & reasoning; Cognitive Dysfunction - cerebrospinal fluid; Cognitive neurology; Data Analysis, Statistics and Probability; Dementia; Executive function; Humans; Magnetic resonance imaging; Memory; MRI; Neurodegeneration; Neuropsychology; Patients; PET; Physics; Positron-Emission Tomography - methods; tau Proteins - metabolism; MRI; Alzheimer's disease; PET; Alzheimer's disease CSF PET plasma tau Subject Categories Biomarkers Neuroscience; Neuroscience; tau Subject Categories Biomarkers; CSF; plasma

ObjectivesTo explore whether regional tau binding measured at baseline is associated with the rapidity of Alzheimer’s disease (AD) progression over 2 years, as assessed by the decline in specified cognitive domains, and the progression of regional brain atrophy, in comparison with amyloid-positron e...