Changes in the heparin neutralising activity of platelet poor plasma after immunisation

Acute myocardial disease, which may be associated with abnormal platelet activity, has been reported after routine immunisation. Thirty-two army apprentices undergoing immunisation were studied for changes in the heparin neutralising activity (HNA) of platelet poor plasma. HNA increased after immuni...

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Bibliographic Details
Published inJournal of clinical pathology Vol. 32; no. 11; pp. 1152 - 1154
Main Authors Baker, I A, Howells, C H, O'Brien, J R
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.11.1979
BMJ Publishing Group LTD
Subjects
Adolescent
Adult
Aged
Antibodies, Bacterial - analysis
Antibodies, Viral - analysis
Heparin - blood
Humans
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Platelet Count
Thrombin Time
Time Factors
Typhoid-Paratyphoid Vaccines - administration & dosage
Typhoid-Paratyphoid Vaccines - immunology
Vaccination
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Summary:Acute myocardial disease, which may be associated with abnormal platelet activity, has been reported after routine immunisation. Thirty-two army apprentices undergoing immunisation were studied for changes in the heparin neutralising activity (HNA) of platelet poor plasma. HNA increased after immunisation. This increase in HNA may represent an increase in platelet activation but may also relate to changes in acute phase proteins. These changes were not observed in elderly subjects undergoing immunisation with influenza vaccine.
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PMID:512030
ObjectType-Article-1
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ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.32.11.1152