The CCL2/CCR2 Axis in the Pathogenesis of HIV-1 Infection: A New Cellular Target for Therapy?

• Published in: Current drug targets Vol. 17; no. 1; p. 76
• Main Authors: Covino, Daniela Angela, Sabbatucci, Michela, Fantuzzi, Laura
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2016
• Subjects: Anti-Retroviral Agents - pharmacology; Chemokine CCL2 - immunology; Drug Discovery; HIV Infections - drug therapy; HIV Infections - immunology; HIV-1 - drug effects; HIV-1 - physiology; Humans; Receptors, CCR2 - immunology; Virus Internalization - drug effects; Virus Replication - drug effects

The identification of chemokine receptors as necessary co-receptors for HIV entry into target cells represented a breakthrough in the understanding of the pathogenesis of this viral infection. Since this initial discovery, it was unraveled that chemokines, in addition to their role in blocking viral...