Upregulation of thyroid transcription factor-1 and human leukocyte antigen class I in Hashimoto's disease providing a clinical evidence for possible triggering autoimmune reaction

• Published in: European journal of endocrinology Vol. 164; no. 5; pp. 795 - 800
• Main Authors: Huang, Huibin, Li, Xisheng, Lin, Ling, Shi, Yaxiong, Lin, Xiahong, Li, Liangyi, Xu, Dongming
• Format: Journal Article
• Language: English
• Published: Bristol BioScientifica 01.05.2011; European Society of Endocrinology
• Subjects: Adult; Aged; Autoantibodies - biosynthesis; Biological and medical sciences; Clinical Study; Endocrinopathies; Female; Fundamental and applied biological sciences. Psychology; Hashimoto Disease - immunology; Hashimoto Disease - metabolism; Hashimoto Disease - pathology; Histocompatibility Antigens Class I - biosynthesis; Histocompatibility Antigens Class I - immunology; HLA Antigens - biosynthesis; HLA Antigens - immunology; Humans; Male; Medical sciences; Middle Aged; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Nuclear Proteins - biosynthesis; Nuclear Proteins - physiology; Thyroid Nuclear Factor 1; Thyroid. Thyroid axis (diseases); Transcription Factors - biosynthesis; Transcription Factors - physiology; Up-Regulation - immunology; Vertebrates: endocrinology; Endocrinopathy; Autoimmunity; Immunopathology; Endocrine gland; Thyroid diseases; Autoimmune disease; Thyroid gland; Reaction; Signal transduction; Hashimoto thyroiditis; Transcription factor; Triggering; Class I histocompatibility antigen; Endocrinology

ObjectiveAn increase in the expression of autoantigens and their presenting molecules human leukocyte antigen (HLA) class I has been demonstrated to be responsible for autoimmune diseases. Thyroid transcription factor-1 (TTF-1 or NKX2-1) synchronously upregulates both HLA class I and thyroid-specifi...