Tissue-specific glucose partitioning and fat content in prediabetes and type 2 diabetes: whole-body PET/MRI during hyperinsulinemia

• Published in: European journal of endocrinology Vol. 184; no. 6; pp. 879 - 889
• Main Authors: Eriksson, Jan W, Visvanathar, Robin, Kullberg, Joel, Strand, Robin, Skrtic, Stanko, Ekström, Simon, Lubberink, Mark, Lundqvist, Martin H, Katsogiannos, Petros, Pereira, Maria J, Ahlström, Håkan
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01.06.2021; Oxford University Press
• Subjects: adipose tissue; Adipose Tissue - diagnostic imaging; Aged; Clinical Study; Diabetes; Diabetes Mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - diagnostic imaging; Diabetes Mellitus, Type 2 - metabolism; diagnostic imaging; Endocrinology and Diabetes; Endokrinologi och diabetes; Female; Glucose; Glucose - metabolism; Glucose Clamp Technique; human; Humans; Hyperinsulinemia; hyperinsulinism; Hyperinsulinism - diagnostic imaging; impaired glucose tolerance; Insulin; Insulin resistance; Insulin Resistance - physiology; Integrated approach; Liver; Magnetic Resonance Imaging; Magnetic Resonance Imaging - methods; Male; Metabolic rate; metabolism; Middle Aged; multimodal imaging; Multimodal Imaging - methods; Muscle; Muscle, Skeletal - diagnostic imaging; Muscle, Skeletal - metabolism; Neuroimaging; non insulin dependent diabetes mellitus; nuclear magnetic resonance imaging; physiology; Positron emission tomography; Positron-Emission Tomography - methods; Prediabetic State; Prediabetic State - diagnostic imaging; procedures; Skeletal; skeletal muscle; Type 2

Objective To obtain direct quantifications of glucose turnover, volumes and fat content of several tissues in the development of type 2 diabetes (T2D) using a novel integrated approach for whole-body imaging. Design and methods Hyperinsulinemic–euglycemic clamps and simultaneous whole-body integrate...