Differential responsiveness of spermatogonia to retinoic acid dictates precocious differentiation but not meiotic entry during steady-state spermatogenesis

• Published in: Biology of reproduction Vol. 108; no. 5; pp. 822 - 836
• Main Authors: Johnson, Taylor A., Niedenberger, Bryan A., Kirsanov, Oleksandr, Harrington, Ellen V., Malachowski, Taylor, Geyer, Christopher B.
• Format: Journal Article
• Language: English
• Published: United States Society for the Study of Reproduction 10.05.2023; Oxford University Press
• Subjects: Animals; Cell differentiation; Cell Differentiation - physiology; Germ cells; Humans; Infant, Newborn; Male; Mammals; Meiosis; Neonates; Pachytene; RA; RESEARCH ARTICLE; Retinoic acid; Semen; spermatocyte; Spermatocytes; Spermatogenesis; Spermatogenesis - physiology; Spermatogonia; Testes; Testis; Tretinoin - pharmacology; spermatogenesis; spermatocyte; spermatogonia; retinoic acid; RA

The foundation of mammalian spermatogenesis is provided by undifferentiated spermatogonia, which comprise of spermatogonial stem cells (SSCs) and transit-amplifying progenitors that differentiate in response to retinoic acid (RA) and are committed to enter meiosis. Our laboratory recently reported t...