Circulating miR-375 as a novel prognostic marker for metastatic medullary thyroid cancer patients

• Published in: Endocrine-related cancer Vol. 25; no. 3; pp. 217 - 231
• Main Authors: Romeo, Paola, Colombo, Carla, Granata, Roberta, Calareso, Giuseppina, Gualeni, Ambra Vittoria, Dugo, Matteo, De Cecco, Loris, Rizzetti, Maria Grazia, Zanframundo, Angela, Aiello, Antonella, Carcangiu, Maria Luisa, Gloghini, Annunziata, Ferrero, Stefano, Licitra, Lisa, Greco, Angela, Fugazzola, Laura, Locati, Laura Deborah, Borrello, Maria Grazia
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01.03.2018
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents - therapeutic use; Biomarkers, Tumor - blood; Carcinoma, Neuroendocrine - blood; Carcinoma, Neuroendocrine - genetics; Carcinoma, Neuroendocrine - pathology; Female; Humans; Male; MicroRNAs - blood; Middle Aged; Piperidines - therapeutic use; Prognosis; Protein Kinase Inhibitors - therapeutic use; Proto-Oncogene Proteins c-ret - genetics; Quinazolines - therapeutic use; ras Proteins - genetics; Thyroid Neoplasms - blood; Thyroid Neoplasms - genetics; Thyroid Neoplasms - pathology; Tumor Burden; Young Adult; medullary thyroid cancer; circulating miRNA; metastases; prognostic biomarker; miR-375

This study aimed to identify circulating miRNAs as novel non-invasive biomarkers for prognosis and vandetanib response in advanced medullary thyroid cancer (MTC) patients. We prospectively recruited two independent cohorts of locally advanced/metastatic MTC patients including a subgroup of vandetani...