Early sepsis care with the National Early Warning Score 2-guided Sepsis Hour-1 Bundle in the emergency department: hybrid type 1 effectiveness-implementation pilot stepped wedge randomised controlled trial (NEWS-1 TRIPS) protocol

• Published in: BMJ open Vol. 14; no. 2; p. e080676
• Main Authors: Lam, Rex Pui Kin, Hung, Kevin Kei Ching, Lui, Chun Tat, Kwok, Wai Shing, Lam, Wendy Wing Tak, Lau, Eric Ho Yin, Sridhar, Siddharth, Ng, Peter Yau Tak, Cheng, Chi Hung, Tsang, Tat Chi, Tsui, Matthew Sik Hon, Graham, Colin Alexander, Rainer, Timothy Hudson
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 01.02.2024; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: accident & emergency medicine; Antibiotics; Clinical medicine; Early Warning Score; Emergency medical care; Emergency medicine; Emergency Service, Hospital; Endorsements; Feasibility; feasibility studies; Hospitals; Humans; Hypotension; Infections; infectious diseases; Intervention; Lactates; Mortality; Patients; Physiology; Pilot projects; qualitative research; randomized controlled trial; Randomized Controlled Trials as Topic; Sepsis; Sepsis - diagnosis; Sepsis - therapy; Vital signs; Hong Kong China; China; feasibility studies; qualitative research; accident & emergency medicine; infectious diseases; randomized controlled trial

IntroductionEarly sepsis treatment in the emergency department (ED) is crucial to improve patient survival. Despite international promulgation, the uptake of the Surviving Sepsis Campaign (SSC) Hour-1 Bundle (lactate measurement, blood culture, broad-spectrum antibiotics, 30 mL/kg crystalloid for hy...