Androgens, oestrogens and endometrium: a fine balance between perfection and pathology

• Published in: Journal of endocrinology Vol. 246; no. 3; pp. R75 - R93
• Main Authors: Gibson, Douglas A, Simitsidellis, Ioannis, Collins, Frances, Saunders, Philippa T K
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01.09.2020
• Subjects: Androgens - metabolism; Endometriosis - metabolism; Endometrium - metabolism; Estrogen Receptor alpha - metabolism; Estrogens - metabolism; Female; Humans; Review; endometriosis; androgen receptor; oestrogen receptor; aromatase; intracrinology

The endometrium is a complex multicellular tissue that is exquisitely sensitive to the actions of sex steroids synthesised in the ovary (endocrine system). Recent studies have highlighted a previously under-appreciated role for local (intracrine) metabolism in fine-tuning tissue function in both hea...