Expression of steroidogenic enzymes in human sebaceous glands

• Published in: Journal of endocrinology Vol. 222; no. 3; pp. 301 - 312
• Main Authors: Inoue, Takayoshi, Miki, Yasuhiro, Kakuo, Shingo, Hachiya, Akira, Kitahara, Takashi, Aiba, Setsuya, Zouboulis, Christos C, Sasano, Hironobu
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01.09.2014
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Androgens - biosynthesis; Androstenedione - biosynthesis; Animals; Cell Line; Child; Cricetinae; Dihydrotestosterone - metabolism; Estradiol Dehydrogenases - genetics; Estradiol Dehydrogenases - metabolism; Female; Gene Expression; Humans; Immunohistochemistry; Lipid Metabolism; Male; Middle Aged; PPAR gamma - metabolism; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Sebaceous Glands - cytology; Sebaceous Glands - enzymology; Sebaceous Glands - metabolism; Sebum - metabolism; Skin - cytology; Skin - metabolism; Testosterone - biosynthesis; TOR Serine-Threonine Kinases - metabolism; Transfection; Young Adult; androgen; sebaceous glands; 17β-HSD2; human skin

Androgens are well known to influence sebum synthesis and secretion. Various factors related to androgen biosynthesis are expressed in human sebaceous glands. In this study, immunohistochemical analysis of human skin specimens from 43 subjects indicated that various androgen-producing and -metaboliz...