The role of gene fusions in the evolution of metabolic pathways: the histidine biosynthesis case

• Published in: BMC evolutionary biology Vol. 7; no. Suppl 2; p. S4
• Main Authors: Fani, Renato, Brilli, Matteo, Fondi, Marco, Lió, Pietro
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.01.2007
• Subjects: Amino Acid Sequence; Archaea - genetics; Archaea - metabolism; Bacteria - genetics; Bacteria - metabolism; Base Sequence; Campylobacter; Escherichia coli; Eukaryotic Cells; Evolution, Molecular; Gene Duplication; Gene Fusion; Genes, Archaeal; Genes, Bacterial; Histidine - biosynthesis; Histidine - genetics; Metabolic Networks and Pathways - genetics; Phylogeny; Salmonella enterica; Sequence Alignment

Histidine biosynthesis is one of the best characterized anabolic pathways. There is a large body of genetic and biochemical information available, including operon structure, gene expression, and increasingly larger sequence databases. For over forty years this pathway has been the subject of extens...