Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection

A 65-year-old man presented with symptoms of severe subcutaneous bleeding in his arm, which led to compartment syndrome requiring fasciotomy and massive blood transfusion protocol. Medical history was significant for history of autoimmune thyroid disease. Workup revealed elevated partial thromboplas...

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Published inBMJ case reports Vol. 14; no. 7; p. e242884
Main Authors Wang, Kevin Y, Shah, Pratik, Roarke, Dennis T, Shakil, Shams A
Format Journal Article
LanguageEnglish
Published London BMJ Publishing Group LTD 20.07.2021
BMJ Publishing Group
Subjects
Abdomen
Anemia
Antibodies
Antigens
Asymptomatic
Blood tests
Case Report
Case reports
Congenital diseases
Cytomegalovirus
Epstein-Barr virus
Hematology
Hemoglobin
Hemophilia
Hepatitis B
Hospitals
Hypothyroidism
Hypoxia
Infections
Medical imaging
Medical screening
Patients
Severe acute respiratory syndrome coronavirus 2
Tuberculosis
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Summary:A 65-year-old man presented with symptoms of severe subcutaneous bleeding in his arm, which led to compartment syndrome requiring fasciotomy and massive blood transfusion protocol. Medical history was significant for history of autoimmune thyroid disease. Workup revealed elevated partial thromboplastin time, decreased factor VIII levels and elevated factor VIII inhibitor levels. He was worked up for causes of acquired haemophilia A and was found to have an elevated SARS-CoV-2 antibody level. Given his negative workup for other secondary aetiologies, we suspect that the cause of his haemophilia A was from his SARS-CoV-2 infection, which has been observed previously in various case reports.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2021-242884