Plant-derived foods for the attenuation of allergic airway inflammation

Asthma is an allergy-mediated inflammatory disease characterised by infiltration of the airway with mast cells, lymphocytes, and eosinophils. The disease is induced by co-ordination of T-helper cell type 2 (Th2) cytokines and inflammatory signal molecules. Fruits and vegetables are a rich source of...

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Published inCurrent pharmaceutical design Vol. 20; no. 6; p. 869
Main Authors Nyanhanda, Tafadzwa, Gould, Elaine M, Hurst, Roger D
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.02.2014
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Abstract Asthma is an allergy-mediated inflammatory disease characterised by infiltration of the airway with mast cells, lymphocytes, and eosinophils. The disease is induced by co-ordination of T-helper cell type 2 (Th2) cytokines and inflammatory signal molecules. Fruits and vegetables are a rich source of polyphenolic bioactive compounds, which have been observed to have health-promoting properties when consumed by humans. In particular, fruit-derived proanthocyanins and anthocyanins have been found to attenuate lung inflammation. Epidemiological studies have revealed correlations between fruit consumption and a lower prevalence of respiratory symptoms and lower incidence of non-specific lung diseases. In this review we summarise the current understanding of the pathophysiologic mechanism(s) involved in the development of allergic airway disease. We also review evidence of the beneficial effects of plant-derived foods, their components and metabolites in allergic airway inflammation arising from in vitro and rodent studies, epidemiological studies and human intervention trials. The mechanism, biological relevance and functional benefits, such as immune modulation (e.g. reduction in cytokine and eotaxin production), antioxidant ability, tissue remodelling and tight junction function are also discussed.
AbstractList Asthma is an allergy-mediated inflammatory disease characterised by infiltration of the airway with mast cells, lymphocytes, and eosinophils. The disease is induced by co-ordination of T-helper cell type 2 (Th2) cytokines and inflammatory signal molecules. Fruits and vegetables are a rich source of polyphenolic bioactive compounds, which have been observed to have health-promoting properties when consumed by humans. In particular, fruit-derived proanthocyanins and anthocyanins have been found to attenuate lung inflammation. Epidemiological studies have revealed correlations between fruit consumption and a lower prevalence of respiratory symptoms and lower incidence of non-specific lung diseases. In this review we summarise the current understanding of the pathophysiologic mechanism(s) involved in the development of allergic airway disease. We also review evidence of the beneficial effects of plant-derived foods, their components and metabolites in allergic airway inflammation arising from in vitro and rodent studies, epidemiological studies and human intervention trials. The mechanism, biological relevance and functional benefits, such as immune modulation (e.g. reduction in cytokine and eotaxin production), antioxidant ability, tissue remodelling and tight junction function are also discussed.
Author Nyanhanda, Tafadzwa
Gould, Elaine M
Hurst, Roger D
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  givenname: Roger D
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  fullname: Hurst, Roger D
  email: tafadzwa.nyanhanda@plantandfood.co.nz
  organization: Food & Wellness Group,, The New Zealand Institute for Plant & Food Research Ltd., Private Bag 3123, Hamilton, 3240, New Zealand. tafadzwa.nyanhanda@plantandfood.co.nz
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23701570$$D View this record in MEDLINE/PubMed
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Snippet Asthma is an allergy-mediated inflammatory disease characterised by infiltration of the airway with mast cells, lymphocytes, and eosinophils. The disease is...
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SubjectTerms Animals
Anthocyanins - chemistry
Anthocyanins - isolation & purification
Anthocyanins - pharmacology
Antioxidants - metabolism
Asthma - immunology
Asthma - physiopathology
Asthma - therapy
Food
Fruit
Humans
Inflammation - immunology
Inflammation - physiopathology
Inflammation - therapy
Plants, Edible - chemistry
Tight Junctions - metabolism
Title Plant-derived foods for the attenuation of allergic airway inflammation
URI https://www.ncbi.nlm.nih.gov/pubmed/23701570
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