VEGF in tumor progression and targeted therapy

• Published in: Current cancer drug targets Vol. 13; no. 4; p. 423
• Main Authors: Chekhonin, Vladimir P, Shein, Sergey A, Korchagina, Anna A, Gurina, Olga I
• Format: Journal Article
• Language: English
• Published: Netherlands 01.05.2013
• Subjects: Angiogenesis Inhibitors - therapeutic use; Animals; Disease Progression; Humans; Molecular Targeted Therapy; Neoplasms - blood supply; Neoplasms - drug therapy; Neoplasms - pathology; Neovascularization, Pathologic - drug therapy; Vascular Endothelial Growth Factor A - antagonists & inhibitors; Vascular Endothelial Growth Factor A - metabolism

Progression of solid tumors depends on vascularization and angiogenesis in a malignant tissue. Among a whole range of proangiogenic factors, a vascular endothelial growth factor A (VEGF-A) plays a key role. Blockade of VEGF may lead to regression of vascular network and inhibition of a tumor growth....