High throughput DNA sequencing to detect differences in the subgingival plaque microbiome in elderly subjects with and without dementia

• Published in: Investigative genetics Vol. 3; no. 1; p. 19
• Main Authors: Cockburn, Andrew F, Dehlin, Jonathan M, Ngan, Tiffany, Crout, Richard, Boskovic, Goran, Denvir, James, Primerano, Donald, Plassman, Brenda L, Wu, Bei, Cuff, Christopher F
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.09.2012; BioMed Central
• Subjects: Aged; Analysis; Dementia; DNA; DNA sequencing; Genes; Genetic aspects; Health aspects; Nucleotide sequencing; Ribosomal RNA; United States

To investigate the potential association between oral health and cognitive function, a pilot study was conducted to evaluate high throughput DNA sequencing of the V3 region of the 16S ribosomal RNA gene for determining the relative abundance of bacterial taxa in subgingival plaque from older adults...