The intervention effect of aspirin on a lipopolysaccharide-induced preeclampsia-like mouse model by inhibiting the nuclear factor-κB Pathway

• Published in: Biology of reproduction Vol. 99; no. 2; pp. 422 - 432
• Main Authors: Li, Guanlin, Ma, Liyang, Lin, Li, Wang, Yan-ling, Yang, Huixia
• Format: Journal Article
• Language: English
• Published: United States Society for the Study of Reproduction 01.08.2018; Oxford University Press
• Subjects: inflammatory factor; lipopolysaccharide; low-dose aspirin; nuclear factor-κB; Preeclampsia; PREGNANCY; Reproductive health; Rodents; nuclear factor-κB; inflammatory factor; preeclampsia; lipopolysaccharide; low-dose aspirin

Preeclampsia is a severe pregnancy-related disorder, and patients usually present with high circulating inflammatory factor levels and excessive activation of the nuclear factor-κB (NF-κB) pathway. Administration of aspirin (ASP) is effective for preventing preeclampsia, and thus, we propose that AS...