Protective Effect of Aloe-emodin on Cognitive Function in Copper-loaded Rats Based on The Inhibition of Hippocampal Neuron Ferroptosis

• Published in: Current neurovascular research Vol. 21; no. 4; p. 458
• Main Authors: Wang, Xie, Chen, Hong, Shao, Nan, Zhang, Xiaoyan, Huang, Chenye, Li, Xiangjun, Zhang, Juan, Chang, Ze, Tang, Le, Xie, Daojun
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 2025
• Subjects: Animals; Anthraquinones - pharmacology; Anthraquinones - therapeutic use; Cognition - drug effects; Copper - toxicity; Ferroptosis - drug effects; Ferroptosis - physiology; Hippocampus - drug effects; Hippocampus - metabolism; Male; Neurons - drug effects; Neurons - metabolism; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Oxidative Stress - drug effects; Rats; Rats, Sprague-Dawley; Sirtuin 1 - metabolism; wilson's disease; hematoxylin & eosin; oxidative stress markers; ferroptosis; Aloe-emodin; cognitive disorders

Aloe-emodin (AE), a monomer derived from traditional Chinese medicine, has demonstrated remarkable efficacy in the clinical management of cognitive disorders. Ferroptosis (FPT), a specialized form of programmed cell death, plays a critical role in the pathological progression of various cognitive di...