Consumption of cranberry polyphenols enhances human γδ-T cell proliferation and reduces the number of symptoms associated with colds and influenza: a randomized, placebo-controlled intervention study

• Published in: Nutrition journal Vol. 12; no. 1; pp. 161 - 738
• Main Authors: Nantz, Meri P, Rowe, Cheryl A, Muller, Catherine, Creasy, Rebecca, Colee, James, Khoo, Christina, Percival, Susan S
• Format: Journal Article
• Language: English
• Published: England Springer-Verlag 13.12.2013; BioMed Central Ltd; BioMed Central
• Subjects: Adult; analysis; beverages; Beverages - analysis; blood serum; Cell Proliferation; Cells, Cultured; chemistry; common cold; Common Cold - epidemiology; Common Cold - immunology; Common Cold - physiopathology; Common Cold - prevention & control; cranberries; Cytokines; Cytokines - secretion; cytology; Double-Blind Method; epidemiology; epithelium; Female; Florida; Florida - epidemiology; Fruit; Fruit - chemistry; Functional Food; Functional Food - analysis; Humans; immunity; immunology; Immunomodulation; Incidence; influenza; Influenza, Human; Influenza, Human - epidemiology; Influenza, Human - immunology; Influenza, Human - physiopathology; Influenza, Human - prevention & control; Leukocytes, Mononuclear; Leukocytes, Mononuclear - cytology; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - pathology; Leukocytes, Mononuclear - secretion; Male; metabolism; mononuclear leukocytes; Non-Nutritive Sweeteners; Non-Nutritive Sweeteners - analysis; pathology; physiopathology; phytochemicals; polyphenols; Polyphenols - analysis; Polyphenols - metabolism; Polyphenols - therapeutic use; prevention & control; Proanthocyanidins; Proanthocyanidins - analysis; Proanthocyanidins - metabolism; Proanthocyanidins - therapeutic use; secretion; Severity of Illness Index; therapeutic use; Vaccinium macrocarpon; Vaccinium macrocarpon - chemistry; Florida

BACKGROUND: Our main objective was to evaluate the ability of cranberry phytochemicals to modify immunity, specifically γδ-T cell proliferation, after daily consumption of a cranberry beverage, and its effect on health outcomes related to cold and influenza symptoms. METHODS: The study was a randomi...