Does des-acyl ghrelin improve glycemic control in obese diabetic subjects by decreasing acylated ghrelin levels?

• Published in: European journal of endocrinology Vol. 170; no. 6; pp. 799 - 807
• Main Authors: Özcan, Behiye, Neggers, Sebastian J C M M, Miller, Anne Reifel, Yang, Hsiu-Chiung, Lucaites, Virginia, Abribat, Thierry, Allas, Soraya, Huisman, Martin, Visser, Jenny A, Themmen, Axel P N, Sijbrands, Eric J G, Delhanty, Patric J D, van der Lely, Aart Jan
• Format: Journal Article
• Language: English
• Published: Bristol Bioscientifica Ltd 01.06.2014; BioScientifica
• Subjects: Acylation; Adult; Biological and medical sciences; Blood Glucose - drug effects; Blood Glucose - metabolism; Clinical Study; Diabetes. Impaired glucose tolerance; Down-Regulation - drug effects; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Fundamental and applied biological sciences. Psychology; Ghrelin - blood; Ghrelin - therapeutic use; Glucose Clamp Technique; Humans; Male; Meals; Medical sciences; Metabolic diseases; Middle Aged; Obesity; Obesity - blood; Obesity - drug therapy; Vertebrates: endocrinology; Endocrinopathy; Human; Glycemic control; Obesity; Diabetes mellitus; Nutrition disorder; Metabolic diseases; Appetite stimulant; Target tissue resistance; Improvement; Ghrelin; Insulin resistance; Endocrinology; Nutritional status; Glycemia

ObjectiveThe objective of this study was to assess the effects of a continuous overnight infusion of des-acyl ghrelin (DAG) on acylated ghrelin (AG) levels and glucose and insulin responses to a standard breakfast meal (SBM) in eight overweight patients with type 2 diabetes. Furthermore, in the same...