Weak Cytotoxic Activity of Miltefosine Against Clinical Isolates of Acanthamoeba spp

• Published in: The Journal of parasitology Vol. 97; no. 3; pp. 538 - 540
• Main Authors: Mrva, M, Garajová, M, Lukáč, M, Ondriska, F
• Format: Journal Article
• Language: English
• Published: Lawrence, KS American Society of Parasitologists 01.06.2011; Allen Press Inc
• Subjects: Acanthamoeba - drug effects; Acanthamoeba castellanii; Acanthamoeba castellanii - drug effects; Acanthamoeba keratitis; Acanthamoeba Keratitis - drug therapy; Acanthamoeba Keratitis - parasitology; Acanthamoeba lugdunensis; Antimicrobials; Antineoplastics; Antiprotozoal Agents - chemistry; Antiprotozoal Agents - pharmacology; Antiprotozoals; Biological and medical sciences; Cancer; Chemotherapy; Cornea - parasitology; Cutaneous leishmaniasis; Cytotoxicity; Dose-Response Relationship, Drug; Fundamental and applied biological sciences. Psychology; General aspects; General aspects and techniques. Study of several systematic groups. Models; Humans; Infections; Invertebrates; Parasites; Parasitology; Penicillin; Phosphorylcholine - analogs & derivatives; Phosphorylcholine - chemistry; Phosphorylcholine - pharmacology; RESEARCH NOTES; Trophozoites; Trophozoites - drug effects; Parasite; Protozoa; Miltefosine; Activity; Lobosea; Acanthamoeba

Hexadecylphosphocholine (miltefosine) is an anticancer drug active in vitro against various protozoan parasites, and recently used for the treatment of disseminated Acanthamoeba infection. In the present study, we present results of weak cytotoxic activity of this potential amoebicidal agent for 2 o...