Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years

• Published in: Gut Vol. 59; no. 7; pp. 969 - 974
• Main Authors: Wong, Vincent Wai-Sun, Wong, Grace Lai-Hung, Choi, Paul Cheung-Lung, Chan, Anthony Wing-Hung, Li, Mia Ka-Po, Chan, Hoi-Yun, Chim, Angel Mei-Ling, Yu, Jun, Sung, Joseph Jao-Yiu, Chan, Henry Lik-Yuen
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.07.2010; BMJ Publishing Group; BMJ Publishing Group LTD
• Subjects: Accuracy; Adult; Aged; Anthropometry - methods; Biological and medical sciences; Biomarkers - blood; Biopsy; Body Mass Index; Cytokines; Digestive system; Disease Progression; Epidemiologic Methods; Exercise; Fatty Liver - diagnosis; Fatty Liver - pathology; Female; Gangrene; Gastroenterology. Liver. Pancreas. Abdomen; Glucose; Hepatitis; Humans; Insulin; Insulin resistance; Investigative techniques, diagnostic techniques (general aspects); Lifestyles; Liver - pathology; Liver cirrhosis; Liver diseases; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Metabolism; Middle Aged; Mortality; Other diseases. Semiology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Physical fitness; Prognosis; Studies; Tumor necrosis factor-TNF; Waist Circumference; Weight Loss; Womens health; Young Adult; Liver biopsy; Prognosis; Non alcoholic steatohepatitis; Gastroenterology; Digestive diseases; Hepatic disease; Evolution

BackgroundPatients with non-alcoholic steatohepatitis (NASH) have increased mortality and liver-related complications. In contrast, simple steatosis is considered benign and non-progressive.ObjectiveTo investigate disease progression in patients with different degrees of non-alcoholic fatty liver di...