Continual monitoring of intraepithelial lymphocyte immunophenotype and clonality is more important than snapshot analysis in the surveillance of refractory coeliac disease

• Published in: Gut Vol. 59; no. 4; pp. 452 - 460
• Main Authors: Liu, H, Brais, R, Lavergne-Slove, A, Jeng, Q, Payne, K, Ye, H, Liu, Z, Carreras, J, Huang, Y, Bacon, C M, Hamoudi, R A, Save, V, Venkatraman, L, Isaacson, P G, Woodward, J, Du, M-Q
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.04.2010; BMJ Publishing Group; BMJ Publishing Group LTD
• Subjects: Aberrant immunophenotype; Adolescent; Adult; Aged; Antigens; Biological and medical sciences; Celiac disease; Celiac Disease - complications; Celiac Disease - immunology; Clinical medicine; clonality analysis; coeliac disease; Female; follow-up; Follow-Up Studies; Gastroenterology. Liver. Pancreas. Abdomen; Gluten; Humans; Immunity, Mucosal; immunohistochemistry; Immunophenotyping; Intestinal Mucosa - immunology; Intestinal Neoplasms - etiology; Intestinal Neoplasms - immunology; intraepithelial T lymphocytes; Lymphocytes; lymphoma; Lymphoma, T-Cell - etiology; Lymphoma, T-Cell - immunology; Male; Medical prognosis; Medical sciences; Middle Aged; Other diseases. Semiology; PCR; Population; Population Surveillance - methods; refractory coeliac disease; Stem Cells - immunology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Studies; Surveillance; T cell receptors; T lymphocytes; T-Lymphocyte Subsets - immunology; Young Adult; Refractory; Immunopathology; Surveillance; Intestinal malabsorption; Gastroenterology; Digestive diseases; Intestinal disease; Coeliac disease; Lymphocyte

ObjectiveAn aberrant immunophenotype and monoclonality of intraepithelial lymphocytes (IELs) are frequently found in refractory coeliac disease (RCD). However, the utility of continual monitoring of IEL immunophenotype and clonality in the surveillance of RCD remains to be studied.DesignThe diagnost...