Reduced left atrial function on exercise in patients with heart failure and normal ejection fraction

• Published in: Heart (British Cardiac Society) Vol. 96; no. 13; pp. 1017 - 1023
• Main Authors: Tan, Y T, Wenzelburger, F, Lee, E, Nightingale, P, Heatlie, G, Leyva, F, Sanderson, J E
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Cardiovascular Society 01.07.2010; BMJ Publishing Group; BMJ Publishing Group LTD
• Subjects: Aged; Atrial Function, Left - physiology; Biological and medical sciences; Blood pressure; Cardiology. Vascular system; Cardiovascular disease; Cardiovascular system; Case-Control Studies; Dyspnea - diagnostic imaging; Dyspnea - etiology; Dyspnea - physiopathology; echocardiography-exercise; exercise; Exercise Tolerance - physiology; Female; Fractions; Heart; Heart attacks; Heart failure; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Heart Failure, Diastolic - complications; Heart Failure, Diastolic - diagnostic imaging; Heart Failure, Diastolic - physiopathology; Humans; Hypertension; Hypertension - complications; Hypertension - diagnostic imaging; Hypertension - physiopathology; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Left atrial function; Male; Medical sciences; Respiratory Function Tests; Stroke Volume - physiology; Ultrasonography; Physical exercise; Human; Heart failure; Cardiovascular disease; Patient; Left atrium; Normal; Heart disease; Exercise tolerance test; Circulatory system; Hemodynamics; Cardiology; Ejection fraction

AimsThe cardinal symptom of heart failure with a normal ejection fraction (HFNEF) is exertional dyspnoea. The authors hypothesised that failure of left atrial (LA) compensatory mechanism particularly on exercise contributes to the genesis of symptoms in HFNEF patients.Methods and ResultsFifty HFNEF...