Role of miRNAs in glucose metabolism of mouse cumulus cells

• Published in: Biology of reproduction Vol. 110; no. 5; pp. 895 - 907
• Main Authors: Ma, Rui-Jie, Zhang, Min, Wu, Jia-Shun, Wang, Zhi-Peng, Wang, Guo-Liang, He, Nan, Luo, Ming-Jiu, Tan, Jing-He
• Format: Journal Article
• Language: English
• Published: United States Society for the Study of Reproduction 09.05.2024; Oxford University Press
• Subjects: Animal models; Animals; cumulus cells; Cumulus Cells - metabolism; Female; Glucose; Glucose - metabolism; glucose 6-phosphate; Glycolysis; Glycolysis - physiology; Metabolism; Metabolites; Mice; microRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; miRNAs; oocyte maturation; Oocytes; Oocytes - metabolism; Oxidative metabolism; Oxidative phosphorylation; pentose phosphate cycle; Pentose Phosphate Pathway; pentoses; phosphates; Phosphorylation; prediction; Pyruvic acid; Quality control; reproduction; RESEARCH ARTICLE; oocyte maturation; miRNAs; pentose phosphate pathway; cumulus cells; glycolysis

It is known that the oocyte has a limited capacity to acquire and metabolize glucose, and it must rely on cumulus cells (CCs) to take up glucose and produce pyruvate for use to produce ATP through oxidative phosphorylation. We therefore propose that miRNAs might regulate glucose metabolism (GM) in C...