Comprehensive gene-expression profile in murine oxygen-induced retinopathy

• Published in: British journal of ophthalmology Vol. 93; no. 1; pp. 96 - 103
• Main Authors: Sato, T, Kusaka, S, Hashida, N, Saishin, Y, Fujikado, T, Tano, Y
• Format: Journal Article
• Language: English
• Published: BMA House, Tavistock Square, London, WC1H 9JR BMJ Publishing Group Ltd 01.01.2009; BMJ Publishing Group; BMJ Publishing Group LTD
• Subjects: Angiogenesis; Animals; Animals, Newborn; Biological and medical sciences; Corneal Neovascularization - genetics; Disease Models, Animal; Gene Expression - genetics; Gene Expression Profiling; Genes; Inflammation; Medical sciences; Mice; Mice, Inbred C57BL; Miscellaneous; Ophthalmology; Oxygen - toxicity; Retinal Diseases - genetics; Retinal Neovascularization - genetics; Retinopathies; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; Studies; Thermal cycling; Up-Regulation; Vascular endothelial growth factor; Eye disease; Vertebrata; Oxygen; Mammalia; Retinopathy; Mouse; Animal; Rodentia; Ophthalmology; Gene expression; Profile

Background/aims:To investigate the correlation between the clinical course and gene-expression pattern in murine oxygen-induced retinopathy (OIR), a commonly used model of retinopathy of prematurity (ROP).Methods:OIR was induced in C57BL/6N mice by placing postnatal day 7 (P7) pups in 75% oxygen for...