Proteases of Plasmodium falciparum as potential drug targets and inhibitors thereof

• Published in: Current topics in medicinal chemistry Vol. 10; no. 3; p. 346
• Main Authors: Wegscheid-Gerlach, Christof, Gerber, Hans-Dieter, Diederich, Wibke E
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.02.2010
• Subjects: Cysteine Endopeptidases - metabolism; Cysteine Proteinase Inhibitors - chemical synthesis; Cysteine Proteinase Inhibitors - chemistry; Cysteine Proteinase Inhibitors - pharmacology; Drug Design; Molecular Structure; Plasmodium falciparum - drug effects; Plasmodium falciparum - enzymology; Structure-Activity Relationship

Malaria, caused by protozoa of the genus Plasmodium, remains one of the most dreadful infectious diseases worldwide killing more than 1 million people per year. The emergence of multidrug-resistant parasites highly demands a steadfast and continuous search not only for new targets but also for new a...