JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study - Milara, Javier; Ballester, Beatriz; Morell, Anselm; Ortiz, José L; Escrivá, Juan; Fernández, Estrella; Perez-Vizcaino, Francisco; Cogolludo, Angel; Pastor, Enrique; Artigues, Enrique; Morcillo, Esteban; Cortijo, Julio (Thorax, 2018)
Keywords: Animals; Blotting, Western; Cell Proliferation - drug effects; Cells, Cultured; Clinical trials; Cytokines; Endothelial Cells; Fluorescent Antibody Technique; Gene expression; Growth factors; Humans; Hypertension, Pulmonary - drug therapy; Hypoxia; Idiopathic Pulmonary Fibrosis - drug therapy; Immunohistochemistry; Janus Kinase 2 - antagonists & inhibitors; Janus Kinase 2 - metabolism; Kinases; Medical prognosis; Myocytes, Smooth Muscle; Phenotype; Phosphorylation; Pulmonary arteries; Pulmonary fibrosis; Pulmonary hypertension; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; RNA, Small Interfering - pharmacology; Rodents; Signal Transduction; Smooth muscle; Transforming Growth Factor beta - pharmacology; Transplants & implants; Triterpenes - pharmacology; Vascular Remodeling - drug effects; Veins & arteries; Ventilation; Spain; BKCa; idiopathic pulmonary fibrosis; JAK2; pulmonary hypertension; Pulmonary artery smooth muscle cells, Pulmonary artery endothelial cells