Partial restoration of GH responsiveness to ghrelin in Cushing's disease after 6 months of ketoconazole treatment: comparison with GHRP-6 and GHRH

• Published in: European journal of endocrinology Vol. 161; no. 5; pp. 681 - 686
• Main Authors: Correa-Silva, Silvia R, Nascif, Sérgio O, Molica, Patrícia, Sá, Larissa B P C, Vieira, José G, Lengyel, Ana-Maria J
• Format: Journal Article
• Language: English
• Published: Bristol BioScientifica 01.11.2009
• Subjects: Adrenals. Adrenal axis. Renin-angiotensin system (diseases); Adult; Area Under Curve; Biological and medical sciences; Clinical Study; Endocrinopathies; Female; Fundamental and applied biological sciences. Psychology; Ghrelin - administration & dosage; Ghrelin - physiology; Growth Hormone-Releasing Hormone - administration & dosage; Growth Hormone-Releasing Hormone - physiology; Growth Hormone-Releasing Hormone - secretion; Human Growth Hormone - blood; Human Growth Hormone - secretion; Humans; Hydrocortisone - blood; Hydrocortisone - urine; Insulin-Like Growth Factor I - metabolism; Ketoconazole - administration & dosage; Male; Medical sciences; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Oligopeptides - administration & dosage; Oligopeptides - physiology; Pituitary ACTH Hypersecretion - drug therapy; Pituitary ACTH Hypersecretion - metabolism; Pituitary ACTH Hypersecretion - physiopathology; Statistics, Nonparametric; Vertebrates: endocrinology; Young Adult; Endocrinopathy; Imidazole derivatives; Adrenal cortex diseases; Ketoconazole; Somatotropin releasing factor; Cushing syndrome; Hyperadrenocorticism; Appetite stimulant; Hypothalamic hormone; Somatotropin; Antifungal agent; Treatment; Growth hormone-releasing hormone; Adenohypophyseal hormone; Partial; Restoration; Ghrelin; Adrenal gland diseases; GH-releasing peptide-6; Hormone releasing factor; Endocrinology; Comparative study

ObjectiveIn Cushing's disease (CD), GH responsiveness to several stimuli, including ghrelin, GHRP-6, and GHRH, is blunted. Recovery of GH secretion after remission of hypercortisolism after transsphenoidal surgery, radiotherapy, or adrenalectomy is controversial. There are no studies evaluating...