Combination treatment in Alzheimer's disease: results of a randomized, controlled trial with cerebrolysin and donepezil

• Published in: Current Alzheimer research Vol. 8; no. 5; p. 583
• Main Authors: Alvarez, X Antón, Cacabelos, R, Sampedro, C, Couceiro, V, Aleixandre, M, Vargas, M, Linares, C, Granizo, E, García-Fantini, M, Baurecht, W, Doppler, E, Moessler, H
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.08.2011
• Subjects: Activities of Daily Living; Aged; Alzheimer Disease - drug therapy; Amino Acids - administration & dosage; Double-Blind Method; Female; Humans; Indans - administration & dosage; Male; Neuroprotective Agents - administration & dosage; Neuropsychological Tests; Piperidines - administration & dosage; Treatment Outcome

Treatment with neurotrophic agents might enhance and/or prolong the effects of cholinesterase inhibitors (ChEIs) in Alzheimer's disease (AD). We compared the safety and efficacy of the neurotrophic compound Cerebrolysin (10 ml; n=64), donepezil (10 mg; n=66) and a combination of both treatments...