Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome

• Published in: Gut Vol. 67; no. 4; pp. 634 - 643
• Main Authors: Zuo, Tao, Wong, Sunny H, Lam, Kelvin, Lui, Rashid, Cheung, Kitty, Tang, Whitney, Ching, Jessica Y L, Chan, Paul K S, Chan, Martin C W, Wu, Justin C Y, Chan, Francis K L, Yu, Jun, Sung, Joseph J Y, Ng, Siew C
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.04.2018; BMJ Publishing Group
• Series: Original article
• Subjects: Abundance; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - therapeutic use; Bacteria; Bacteriophages; Case-Control Studies; Clinical outcomes; Clostridium difficile; Clostridium Infections - therapy; Diarrhea; Dysbacteriosis; Fecal Microbiota Transplantation; Feces; Female; Gastroenterology; Gut Microbiota; Humans; Inflammatory bowel disease; Male; Microbiomes; Microbiota; Middle Aged; Nosocomial infections; Patients; Phages; Recurrent infection; rRNA 16S; Systematic review; Transplantation; Treatment Outcome; Vancomycin; Vancomycin - therapeutic use; Virus-like particles; Viruses; United States > US; BACTERIAL INFECTION; MUCOSAL INFECTION

ObjectiveFaecal microbiota transplantation (FMT) is effective for the treatment of recurrent Clostridium difficile infection (CDI). Studies have shown bacterial colonisation after FMT, but data on viral alterations in CDI are scarce. We investigated enteric virome alterations in CDI and the associat...