Equine pregnancy-specific glycoprotein CEACAM49 secreted by endometrial cup cells activates TGFB

• Published in: Reproduction (Cambridge, England) Vol. 160; no. 5; pp. 685 - 694
• Main Authors: Kammerer, Robert, Ballesteros, Angela, Bonsor, Daniel, Warren, James, Williams, John M, Moore, Tom, Dveksler, Gabriela
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01.11.2020
• Subjects: Animals; Carcinoembryonic Antigen - metabolism; Endometrium - immunology; Endometrium - metabolism; Endometrium - pathology; Female; Glycoproteins - metabolism; Horses; Pregnancy; T-Lymphocytes, Regulatory - immunology; Transforming Growth Factor beta1 - genetics; Transforming Growth Factor beta1 - metabolism; Trophoblasts - immunology; Trophoblasts - metabolism; Trophoblasts - pathology

In early equine pregnancy, a highly invasive trophoblast cell subpopulation, the chorionic girdle cells, invade the endometrium and form endometrial cups (EC). These cells express classical MHC molecules, thereby stimulating a humoral and cellular immune response, resulting in a massive accumulation...