Manganese(III) Promoted Cyclization of N-alkenyl-N-(2-hydroxyethyl) amides to Iso-Oxacepham Potent beta-Lactamase Inhibitors

• Published in: Letters in organic chemistry Vol. 14; no. 5; pp. 337 - 346
• Main Authors: Punda, Pawel, Schielmann, Marta, Makowiec, Slawomir
• Format: Journal Article
• Language: English
• Published: SHARJAH Bentham Science Publ Ltd 01.06.2017
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; radical cyclizations; FREE-RADICAL CYCLIZATIONS; beta-lactams; beta-lactamase inhibitors; iso-oxacephams; 1-OXACEPHAMS; REACTIVITY; ISOCEPHEMS; cyclization; N-alkenylamides; IN-VITRO ACTIVITY; ENAMIDES

Background: beta-Lactams are still a subject of interest of organic chemists. The main reason for this interest is due to their application as a chemotherapeutic. beta-Lactam antibiotics are still the most commonly used drugs in bacterial infections. Method: Methods using 4-exo-trig radical cyclizat...