Preimplantation chromosomal mosaics, chimaeras and confined placental mosaicism

• Published in: Reproduction & fertility Vol. 3; no. 2; pp. R66 - R90
• Main Authors: West, John D, Everett, Clare A
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01.04.2022; Bioscientifica
• Subjects: Aneuploidy; Animals; Blastocyst; chimaera; chromosomal mosaic; Chromosomes; confined placental mosaicism; Female; Humans; mixoploidy; Mosaicism; Placenta; Pregnancy; Review; aneuploidy; mixoploidy; chimaera; confined placental mosaicism; chromosomal mosaic

Some human preimplantation embryos are chromosomally mosaic. For technical reasons, estimates of the overall frequency vary widely from <15 to >90% and the true frequency remains unknown. Aneuploid/diploid and aneuploid/aneuploid mosaics typically arise during early cleavage stages before the...