Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD

• Published in: BMC neurology Vol. 6; no. 1; p. 44
• Main Authors: Momeni, Parastoo, Schymick, Jennifer, Jain, Shushant, Cookson, Mark R, Cairns, Nigel J, Greggio, Elisa, Greenway, Matthew J, Berger, Stephen, Pickering-Brown, Stuart, Chiò, Adriano, Fung, Hon Chung, Holtzman, David M, Huey, Edward D, Wassermann, Eric M, Adamson, Jennifer, Hutton, Michael L, Rogaeva, Ekaterina, St George-Hyslop, Peter, Rothstein, Jeffrey D, Hardiman, Orla, Grafman, Jordan, Singleton, Andrew, Hardy, John, Traynor, Bryan J
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.12.2006; BioMed Central; BMC
• Subjects: Amyotrophic Lateral Sclerosis - complications; Amyotrophic Lateral Sclerosis - epidemiology; Amyotrophic Lateral Sclerosis - genetics; Base Sequence; Chromosome Aberrations - statistics & numerical data; Chromosome Mapping; Chromosomes, Human, Pair 9 - genetics; Dementia - complications; Dementia - epidemiology; Dementia - genetics; Genetic Predisposition to Disease - epidemiology; Genetic Predisposition to Disease - genetics; Heterozygote; Humans; Male; Middle Aged; Molecular Sequence Data; Mutation; North America; Polymorphism, Single Nucleotide - genetics; Prevalence; Risk Assessment - methods; Risk Factors; North America

A new locus for amyotrophic lateral sclerosis--frontotemporal dementia (ALS-FTD) has recently been ascribed to chromosome 9p. We identified chromosome 9p segregating haplotypes within two families with ALS-FTD (F476 and F2) and undertook mutational screening of candidate genes within this locus. Can...