Whole Transcriptome Sequencing of Peripheral Blood Identifies the Alzheimer's Disease-Related circRNA-miRNA-lncRNA Pathway

• Published in: Current neurovascular research Vol. 21; no. 2; p. 184
• Main Authors: Gu, Yucheng, Chen, Nihong, Zhu, Lin, Chen, Xiangliang, Jiang, Teng, Zhang, Yingdong
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2024
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - blood; Alzheimer Disease - genetics; Cognitive Dysfunction - blood; Cognitive Dysfunction - genetics; Female; Gene Expression Profiling - methods; Gene Regulatory Networks - genetics; Humans; Male; MicroRNAs - blood; MicroRNAs - genetics; Middle Aged; RNA, Circular - blood; RNA, Circular - genetics; RNA, Long Noncoding - blood; RNA, Long Noncoding - genetics; Transcriptome; whole transcriptome sequencing; Alzheimer’s disease continuum; mild cognitive impairment; clinical dementia rating; Alzheimer’s dementia; circRNA-miRNA-lncRNA

Previous studies on transcriptional profiles suggested dysregulation of multiple RNA species in Alzheimer's disease. However, despite recent investigations revealing various aspects of circular RNA (circRNA)-associated competing endogenous RNA (ceRNA) networks in Alzheimer's Disease (AD) p...