Autoimmune encephalitis associated with anti-LGI1 antibody: a potential cause of neuropsychiatric systemic lupus erythematosus

• Published in: Lupus science & medicine Vol. 12; no. 1; p. e001429
• Main Authors: Chen, Sixian, Ren, Haitao, Fan, Siyuan, Zhang, Shangzhu, Li, Mengtao, Guan, Hongzhi
• Format: Journal Article
• Language: English
• Published: England Lupus Foundation of America 18.02.2025; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Adrenal Cortex Hormones - therapeutic use; Antibodies; Autoantibodies - blood; Autoantibodies - immunology; Autoimmune Diseases; Biomarker Studies; Biopsy; Brain research; Cerebrospinal fluid; Consciousness; Convulsions & seizures; Diagnostic tests; Disease; Drug dosages; Electroencephalography; Encephalitis; Glioma; Hospitals; Humans; Hyponatremia; Immunoglobulins; Immunoglobulins, Intravenous - therapeutic use; Intracellular Signaling Peptides and Proteins - immunology; Laboratories; Leukocytes; Limbic Encephalitis - blood; Limbic Encephalitis - diagnosis; Limbic Encephalitis - drug therapy; Limbic Encephalitis - immunology; Lupus; Lupus Erythematosus, Systemic; Lupus Vasculitis, Central Nervous System - blood; Lupus Vasculitis, Central Nervous System - diagnosis; Lupus Vasculitis, Central Nervous System - drug therapy; Lupus Vasculitis, Central Nervous System - immunology; Magnetic Resonance Imaging; Memory; Metabolism; Original Research; Patients; Pneumonia; Respiratory failure; Sodium; Antibodies; Autoimmune Diseases; Lupus Erythematosus, Systemic

ObjectiveTo investigate the clinical features and treatment outcomes of anti-leucine-rich glioma-inactivated 1 (anti-LGI1) encephalitis in patients with SLE.MethodsBetween October 2014 and April 2024, serum or cerebrospinal fluid samples were collected from 332 patients with SLE suspected of autoimm...