Spatial colocalization and combined survival benefit of natural killer and CD8 T cells despite profound MHC class I loss in non-small cell lung cancer

• Published in: Journal for immunotherapy of cancer Vol. 12; no. 9; p. e009126
• Main Authors: Wessel, Remziye E, Ageeb, Nardin, Obeid, Joseph M, Mauldin, Ileana S, Goundry, Kate A, Hanson, Gabriel F, Hossain, Mahdin, Lehman, Chad, Gentzler, Ryan D, Wages, Nolan A, Slingluff, Craig L, Bullock, Timothy N J, Dolatshahi, Sepideh, Brown, Michael G
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd 18.09.2024; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Antibodies; Antigens; Basic Tumor Immunology; Carcinoma, Non-Small-Cell Lung - immunology; Carcinoma, Non-Small-Cell Lung - mortality; Carcinoma, Non-Small-Cell Lung - pathology; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cells; Cloning; Cytokines; Cytotoxicity; Female; Histocompatibility Antigens Class I - immunology; Histocompatibility Antigens Class I - metabolism; Humans; Immunity (Disease); Immunohistochemistry; Immunotherapy; Killer Cells, Natural - immunology; Killer Cells, Natural - metabolism; Lung Cancer; Lung Neoplasms - immunology; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Lymphatic system; Lymphocytes; Lymphocytes, Tumor-Infiltrating - immunology; Lymphocytes, Tumor-Infiltrating - metabolism; Major histocompatibility complex - MHC; Male; Medical prognosis; Natural killer - NK; Original Research; Patients; Squamous cell carcinoma; T cell; Tumor infiltrating lymphocyte - TIL; Tumors; United States > US; California; Natural killer - NK; Lung Cancer; Tumor infiltrating lymphocyte - TIL; Major histocompatibility complex - MHC; T cell

BackgroundMajor histocompatibility complex class I (MHC-I) loss is frequent in non-small cell lung cancer (NSCLC) rendering tumor cells resistant to T cell lysis. NK cells kill MHC-I-deficient tumor cells, and although previous work indicated their presence at NSCLC margins, they were functionally i...