Rhinovirus upregulates transient receptor potential channels in a human neuronal cell line: implications for respiratory virus-induced cough reflex sensitivity

• Published in: Thorax Vol. 69; no. 1; pp. 46 - 54
• Main Authors: Abdullah, H, Heaney, L G, Cosby, S L, McGarvey, L P A
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.01.2014
• Subjects: Asthma; Calcium Channels - physiology; Cell Line; Cells; Cough - physiopathology; Cough - virology; Flow Cytometry; Human rhinovirus; Humans; Infections; Nerve Tissue Proteins - physiology; Neuroblastoma; Picornaviridae Infections; Proteins; Respiratory Tract Infections - physiopathology; Respiratory Tract Infections - virology; Rhinovirus - physiology; Statistical analysis; Transient Receptor Potential Channels - physiology; TRPA1 Cation Channel; TRPM Cation Channels - physiology; TRPV Cation Channels - physiology; Tumor Cells, Cultured; Up-Regulation - physiology; Viral infections; Virus Diseases - physiopathology; Virus Replication - physiology; Viruses; United Kingdom > UK; United States > US; Germany; Respiratory Infection; Asthma Pharmacology; Asthma Mechanisms; Cough/Mechanisms/Pharmacology; Airway Epithelium; Cytokine Biology; Viral infection; Asthma

Background The mechanism underlying respiratory virus-induced cough hypersensitivity is unknown. Upregulation of airway neuronal receptors responsible for sensing physical and chemical stimuli is one possibility, and the transient receptor potential (TRP) channel family are potential candidates. We...