Computer-Aided Drug Discovery and Design Targeting Ion Channels

• Published in: Current topics in medicinal chemistry Vol. 16; no. 16; p. 1819
• Main Authors: Zhang, Qiansen, Gao, Zhaobing, Yang, Huaiyu
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.07.2016
• Subjects: Animals; Binding Sites - drug effects; Computer-Aided Design; Drug Discovery; Humans; Ion Channels - antagonists & inhibitors; Ion Channels - metabolism

Ion channels are widely expressed in living cells and play critical roles in various cellular biological functions. Dysfunctional ion channels can cause a variety of diseases, making ion channels attractive targets for drug discovery. Computational approaches, such as molecular docking and molecular...