Identification of functional CCAAT/enhancer-binding protein and Ets protein binding sites in the human chorionic somatomammotropin enhancer sequences

• Published in: Journal of molecular endocrinology Vol. 47; no. 2; pp. 179 - 193
• Main Authors: Lytras, Aristides, Detillieux, Karen, Cattini, Peter A
• Format: Journal Article
• Language: English
• Published: England Society for Endocrinology 01.10.2011; BioScientifica
• Subjects: Binding Sites; CCAAT-Enhancer-Binding Proteins - metabolism; Cell Line, Tumor; Chromatin Immunoprecipitation; Electrophoretic Mobility Shift Assay; Enhancer Elements, Genetic - genetics; Humans; Placental Lactogen - genetics; Promoter Regions, Genetic - genetics; Protein Binding - genetics; Proto-Oncogene Proteins c-ets - metabolism; Regular papers

The human chorionic somatomammotropin (CS) A and B genes (listed as CSH1 and CSH2 in the HUGO database) are highly expressed in placenta. A 241 bp potent enhancer, nucleotides (nts) 1–241, located at the 3′ end of the CS-B gene (CS-Benh) stimulates promoter activity specifically in placental trophob...