Pregnancy-specific glycoproteins: evolution, expression, functions and disease associations

• Published in: Reproduction (Cambridge, England) Vol. 163; no. 2; pp. R11 - R23
• Main Authors: Moore, Tom, Williams, John M, Becerra-Rodriguez, Maria Angeles, Dunne, Matthew, Kammerer, Robert, Dveksler, Gabriela
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01.02.2022
• Subjects: Animals; DNA Copy Number Variations; Female; Glycoproteins - metabolism; Horses; Mammals - metabolism; Phylogeny; Placenta - metabolism; Placentation; Pregnancy; Review; Trophoblasts - metabolism

Pregnancy-specific glycoproteins (PSGs) are members of the immunoglobulin superfamily and are closely related to the predominantly membrane-bound CEACAM proteins. PSGs are produced by placental trophoblasts and secreted into the maternal bloodstream at high levels where they may regulate maternal im...